I-Pustular Psoriasis: Izimbangela, Izinhlobo, kanye Nokwelashwa

I-Pustular psoriasis iyindlela engajwayelekile kodwa ebalulekile ye-psoriasis ebonakaliswa ngama-pustules ahlanzekile (angavuthiwe) esikhumbeni esivuvukalayo, esibomvu. Ngokwehlukile kwi-plaque psoriasis ejwayelekile, ama-blister amhlophe noma aphuzi abamba isikhala esikhulu — lawo awanabacteria. Lesi simo sihlukaniswe ngezinhlobo ezithile (izandla, izinyawo) kanye nezinhlobo ezijulile (ezithinta umzimba wonke). Uhlobo olujulile lungaba yingozi empilweni futhi ludinga ukwelashwa kwezokwelapha okuphuthumayo.

Izinhlobo eziyinhloko zimi kanje: I-pustular psoriasis ejulile (GPP, uhlobo lwe-von Zumbusch) — ukuqala okuphuthumayo okuhlanganisa umkhuhlane, ukuvuvukala okwandile, kanye nokwakheka kwepustule emzimbeni, okungenzeka kube yingozi empilweni. I-palmoplantar pustulosis (uhlobo lwe-Barber) — ama-pustules ahlanzekile, aphuzi ezandleni nasemathangeni athinta kakhulu impilo yansuku zonke. I-acrodermatitis continua ye-Hallopeau — ukuvuthwa okuqhubekayo kwepustule eziphezu kwezinyawo nezinyawo ezingaholela ekulahlekelweni kwezinzipho nasekushintsheni kwemathambo.

I-pustular psoriasis ibangelwa ukuvuselelwa kakhulu kohlelo lokuzivikela komzimba, okuholela ekuthuthukisweni okukhulu kokuhamba kwe-neutrophil kwi-epidermis. Izimbangela ezivamile zifaka: ukuhoxiswa okuphuthumayo kwe-corticosteroids ezisemqoka, izifo (ikakhulukazi i-streptococcal), ukukhulelwa (impetigo herpetiformis), ukucindezeleka okukhulu, imithi ethile, nokubhema. Ukuhluka kwemithambo ye-IL36RN kuvele kutholakale ezimweni zomndeni ze-GPP.

Ngendlela ejwayelekile, ububomvu obubanzi besikhumba obunezinkulungwane ze-pustules ezincane buvele ngokuzumayo, kuhambisana nefever, izikhukhula, i-tachycardia, kanye nokungazizwa kahle. Ama-pustules angahlangana abe nemifula ye-pus. Izinkinga zifaka ukulahleka kwamanzi nezinto eziphilayo, i-sepsis, kanye nokwehluleka kwemithambo.!! Ngendlela ye-palmoplantar, ama-pustules abuhlungu nokukhuhla ezandleni nasezinyaweni kubalulekile — ngokuvamile kuhambisana nokuphazamiseka okukhulu kokusebenza.

Ukuxilongwa kusekelwe esithombeni sekliniki nase-biopsy yesikhumba, ebonisa ukuhamba kwe-pustule ngaphansi kwe-corneal nge-neutrophil infiltration — ngaphandle kokutholwa kwe-pathogen (ama-pustules ahlanzekile). Izivivinyo zebhuku ngokuvamile zikhombisa izinkomba zokuvuvukala eziphezulu (CRP, ESR), i-leukocytosis, futhi kungenzeka i-hypoalbuminemia. Ukuhlukanisa phakathi kwe-pustuloses ezithathelwana nezinye i-dermatoses ze-neutrophilic kubalulekile.

Ukwelashwa kuncike endleleni nasekuphakanyisweni. I-GPP ivame ukufuna ukungena esibhedlela ngemithi esebenzayo: i-cyclosporine yokulawula ngokushesha, i-methotrexate, i-acitretin, noma ama-biologics (i-infliximab, i-spesolimab — i-antagonist ethile ye-IL-36 receptor). Ngendlela ye-palmoplantar, ama-steroids aphezulu, i-PUVA therapy, i-acitretin, kanye nama-biologics kuyizinketho. Ukugwema izimbangela ezaziwayo kubalulekile, ikakhulukazi ukuhoxiswa kancane kwe-steroids ezisemqoka kunokuhoxiswa okuphuthumayo.!!

I-pustular psoriasis — ikakhulukazi indlela ye-palmoplantar — ifuna ukuqapha ngokucophelela ukuze kulandelwe ubukhulu bokuphuma kanye nempendulo yokwelashwa. I-Skinscanner ikuvumela ukuthi uthathe izithombe zezingalo zakho, izinyawo, noma ezinye izindawo ezithintekile njalo, kudala irekhodi elibonakalayo eliqopha ubukhulu be-pustule, ububomvu, nokukhuhla ngokuhamba kwesikhathi. Le ndaba ibalulekile ezihlanganweni ze-dermatology, isiza udokotela wakho ukuthi abheke ukuthi imithi yakho yamanje iyawulawula yini lesi sifo noma uma kudingeka izinguquko.

Kubaguli abaziwa nge-psoriasis, le app ingasiza ekutholeni izimpawu zokuqala zokuphuma kwe-pustular — ama-pustules amasha avele esikhumbeni esivamile — okuvumela ukungenelela ngesikhathi. I-Skinscanner ayithathi indawo yokuhlola kwezobuchwepheshe, okuyinto ebalulekile kulolu sifo olungaba yingozi, kodwa isekela ukuqapha okwaziwayo nokuxoxisana okuphumelelayo kwezokwelapha.