Lentigo melanoma is mainly caused by long‑term cumulative sun damage to the skin, especially on the face, leading to malignant change in pigment cells within a pre‑existing patch called lentigo maligna. Genetic predisposition, fair skin, and reduced antitumor immunity also play a role in who develops this type of melanoma.
Lentigo melanoma carries a high risk of local recurrence and spread to lymph nodes and internal organs once it invades deeper skin layers. The risk is higher in older, fair‑skinned people with heavy lifetime sun exposure, a history of sunburns, or previous melanoma.
The main treatment for lentigo melanoma is wide surgical excision with safety margins, sometimes combined with lymph node surgery if spread is suspected. In more advanced cases, additional treatments like immunotherapy, targeted therapy, chemotherapy, or radiation may be used, while local destructive methods such as laser or freezing are not appropriate for this cancer.