Akukho sizathu sinye se-squamous cell carcinoma, kodwa ukuvezwa ixesha elide kwe-UV, imitha, iikhemikhali ezithile, ukulimala kolusu olungapheliyo, kunye nezinye izifo zolusu ezingaqhelekanga zonke zonyusa umngcipheko. Kwezinye iimeko, i-human papillomavirus (HPV) kunye nenkqubo yokuzikhusela ebuthathaka nayo idlala indima.
I-SCC inokubuya emva konyango kwaye, kwezinye iimeko, isasazeke kumaseli omzimba aseduze okanye kwizitho ezikude, ngakumbi xa inkulu, inzulu, okanye ihlala ixesha elide. Abantu abane-SCC enye banethuba eliphezulu lokuphuhlisa olunye umhlaza wesikhumba kwixesha elizayo kwaye bafuna ukuhlolwa kolusu rhoqo.
Unyango oluphambili lwe-squamous cell carcinoma kukususwa ngokupheleleyo komhlaza ngokuhlinzwa okupheleleyo kunye nolusu olusempilweni. Ngokobukhulu, ubunzulu, kunye nendawo, oogqirha banokusebenzisa i-radiotherapy, ukuhlinzwa okukhethekileyo (okufana ne-Mohs), okanye, kwiimeko eziphambili, unyango oluqhelekileyo olufana ne-immunotherapy okanye i-chemotherapy.