Amathumba ayisicaba abangelwa kukutheleleka kweengqimba eziphezulu zesikhumba nge-human papillomavirus (HPV), ngokuqhelekileyo iintlobo eziphantsi kwingozi. Uninzi lwabantu bathwala i-HPV, kodwa amathumba avele kuphela xa kukho izinto ezongezelelweyo ezifana nokuncipha kwamandla omzimba, ukulimala kwesikhumba, okanye ukunakekelwa kwesikhumba okunganele okwenza kube lula i-virus ukuba iqale ukukhula.
Amathumba ayisicaba athathwa njengaphephile xa kuziwa kwingozi yomdlavuza kwaye phantse awaguquki abe yingozi. Iingxaki eziphambili kukuphazamiseka kokubukeka, ukopha okungenzeka okanye ubuhlungu ukuba zihlala zilimala, kunye nokuthambekela kokusabalala okanye ukuphindaphinda esikhumbeni.
Amathumba ayisicaba angasuswa ngezindlela ezithambile ezifana ne-laser, i-nitrogen ewuketshezi (cryotherapy), ukuhlinzwa ngamaza omsakazo, okanye i-electrocoagulation. Kwezinye izimo, ukusikwa kokuhlinzwa nge-histology kuyasetshenziswa, ikakhulukazi ukuba isimo singacacile. Ukuzisika, ukushisa, okanye ukuklwebha amathumba akuphephile kwaye kungabangela ukopha, ukutheleleka, amanxeba, nokuthola isimo esingalungile. Ngisho nangemva kokususwa, amathumba amasha angavela, ngoko ukulandela nokuvimbela kubalulekile.