The exact cause of pustular psoriasis is not fully understood, but it involves an overactive immune response in genetically predisposed people. Flares are often triggered by certain medications, sudden steroid withdrawal, infections, smoking, stress, or strong skin irritation.
You’re at higher risk of pustular psoriasis if you already have psoriasis, smoke, take certain medications, or have sudden changes in steroid treatment. Generalized forms can affect the whole body and may lead to serious complications involving the blood, kidneys, and liver.
Treatment focuses on calming inflammation, removing thick scales, and preventing complications, using a mix of creams and systemic medicines. Depending on severity, doctors may use keratolytic creams, topical steroids, calcineurin inhibitors, retinoids, immunosuppressants, and modern biologic drugs, plus phototherapy in stable cases.