IMelanoma ithuthuka lapho ama-melanocyte eqongelela ukulimala kofuzo bese ephenduka abe ngumdlavuza, ngokuvamile ngaphansi kwethonya lemisebe ye-ultraviolet kanye nokuthambekela okufunwa. Kubantu abaningi, akukho sizathu esisodwa esicacile esingatholakala, kodwa inhlanganisela yokuchayeka kwe-UV, uhlobo lwesikhumba, kanye nofuzo kudlala indima.
Izici eziyinhloko ezibeka engcupheni ye-melanoma ukuvezwa okukhulu noma okuphindaphindiwe kwe-UV, isikhumba esikhanyayo esishiswa kalula, amabala amaningi noma angajwayelekile, umlando womuntu siqu noma womndeni we-melanoma, kanye nobudala obudala. Isikhumba esinsundu sinokuzivikela okuthile, kodwa i-acral ne-subungual melanomas isenzeka futhi ivame ukutholakala kamuva.
Ukwelashwa okuyinhloko kwe-melanoma ukususa ngokuhlinzwa ngendawo ephephile yesikhumba esijwayelekile ezungeze umdlavuza. Uma izindlala zomzimba noma izitho ezikude zihilelekile, ukwelashwa kungase futhi kufake ukuhlinzwa kwezindlala zomzimba, ukwelashwa komzimba, ukwelashwa okuqondisiwe, ukwelashwa ngomuthi, kanye/noma imisebe, okukhethwe ngudokotela wezifo zomdlavuza ngokusekelwe esigabeni.