Amathumba ayisicaba abangelwa ukutheleleka kwezingqimba eziphezulu zesikhumba nge-human papillomavirus (HPV), ngokuvamile izinhlobo eziphansi ezingcupheni. Abantu abaningi bathwala i-HPV, kodwa amathumba avele kuphela uma kunezici ezengeziwe ezifana nokuncipha kwamandla omzimba, ukulimala kwesikhumba, noma ukunakekelwa kwesikhumba okunganele okwenza kube lula i-virus ukuba iqale ukukhula.
Amathumba ayisicaba abhekwa njengaphephile uma kuziwa engcupheni yomdlavuza futhi cishe awaguquki abe yingozi. Izinkinga eziyinhloko ukuvikelwa kokubukeka, ukopha okungenzeka noma ubuhlungu uma zihlala zilimala, kanye nokuthambekela kokusabalala noma ukuphindaphinda esikhumbeni.
Amathumba ayisicaba angasuswa ngezindlela ezithambile ezifana ne-laser, i-nitrogen ewuketshezi (cryotherapy), ukuhlinzwa ngamaza omsakazo, noma i-electrocoagulation. Kwezinye izimo, ukusikwa kokuhlinzwa nge-histology kuyasetshenziswa, ikakhulukazi uma isimo singacacile. Ukuzisika, ukushisa, noma ukuklwebha amathumba akuphephile futhi kungabangela ukopha, ukutheleleka, amanxeba, nokuthola isimo esingalungile. Ngisho nangemva kokususwa, amathumba amasha angavela, ngakho ukulandela nokuvimbela kubalulekile.