Ayikho imbangela eyodwa ye-squamous cell carcinoma, kodwa ukuvezwa isikhathi eside kwe-UV, imisebe, amakhemikhali athile, ukulimala kwesikhumba okungapheli, nezinye izifo zesikhumba ezingavamile konke kukhuphula ingozi. Kwezinye izimo, i-human papillomavirus (HPV) kanye nesistimu yokuzivikela ebuthakathaka nakho kudlala indima.
I-SCC ingabuya ngemva kokwelashwa futhi, kwezinye izimo, isakazeke kumaseli omzimba aseduze noma izitho ezikude, ikakhulukazi uma inkulu, ijulile, noma ihlala isikhathi eside. Abantu abane-SCC eyodwa banethuba eliphakeme lokuthuthukisa omunye umdlavuza wesikhumba esikhathini esizayo futhi badinga ukuhlolwa kwesikhumba njalo.
Ukwelashwa okuyinhloko kwe-squamous cell carcinoma ukususa ngokuphelele umdlavuza ngokuhlinzwa okuphelele nesikhumba esinempilo. Ngokwesayizi, ukujula, nendawo, odokotela bangase futhi basebenzise i-radiotherapy, ukuhlinzwa okukhethekile (okufana ne-Mohs), noma, ezimweni ezithuthukile, ukwelashwa okujwayelekile okufana ne-immunotherapy noma i-chemotherapy.